Name: mTOR inhibitor WYE-28
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321071
Cas No:1062172-60-4
常用名:mTOR inhibitor WYE-28
别名:mTOR抑制剂 WYE-28, mTOR inhibitor WYE28, mTOR inhibitor WYE 28
别名:mTOR抑制剂 WYE-28, mTOR inhibitor WYE28, mTOR inhibitor WYE 28
IUPAC:methyl 4-{6-[4-({[4-(hydroxymethyl)phenyl]carbamoyl}amino)phenyl]-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidine-1-carboxylate
IUPAC:methyl 4-{6-[4-({[4-(hydroxymethyl)phenyl]carbamoyl}amino)phenyl]-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl}piperidine-1-carboxylate
InChI key:DLIGFKRUAOAIBA-UHFFFAOYSA-N

分子式:C30H34N8O5
分子量:586.653
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1
SMILES:COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(NC(=O)Nc2ccc(CO)cc2)cc1)N1CCOCC1

mTOR inhibitor WYE-28是一种mTOR抑制剂(IC50=0.08 nM)和PI3Kα抑制剂(IC50=6 nM)，在裸鼠微粒体中的半衰期为13分钟。

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