Name: PROTAC IDO1 Degrader-1
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321082
Cas No:2488851-89-2
常用名:PROTAC IDO1 Degrader-1
别名:PROTAC IDO1 Degrader-1
IUPAC:(Z)-N-(3-bromo-4-fluorophenyl)-4-(27-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-7,10,13,16,19,22,25-heptaoxa-1,4-diazaheptacosan-1-yl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
IUPAC:(Z)-N-(3-bromo-4-fluorophenyl)-4-(27-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-7,10,13,16,19,22,25-heptaoxa-1,4-diazaheptacosan-1-yl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
InChI key:BVQZWOPTIZSOAW-UHFFFAOYSA-N

分子式:C40H53BrFN9O13
分子量:966.816
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
SMILES:O\N=C(/Nc1ccc(F)c(Br)c1)c1nonc1NCCNCCOCCOCCOCCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1].

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。

电话：400820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~