Name: C6 Urea Ceramide
Rating: 5 (10 reviews)

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HIT ID:HIT214321084
Cas No:486991-52-0
常用名:C6 Urea Ceramide
IUPAC:1-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]-3-hexylurea
IUPAC:1-[(2S,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]-3-hexylurea
InChI key:MIADELGCYXNHNP-VYQUXUJXSA-N

分子式:C25H50N2O3
分子量:426.686
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)NCCCCCC
SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)NC(=O)NCCCCCC

C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.

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