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  3. HIT214321085
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HIT214321085
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HIT214321085
  • HIT ID:HIT214321085
  • Cas No:175892-43-0
  • 常用名:C8 D-threo Ceramide (d18:1/8:0)
  • 别名:C8 D-threo Ceramide (d18:1/8:0)
  • IUPAC:N-[(2R,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
    IUPAC:N-[(2R,3R,4E)-1,3-dihydroxyoctadec-4-en-2-yl]octanamide
  • InChI key:APDLCSPGWPLYEQ-BKSWAVPISA-N
  • 分子式:C26H51NO3
  • 分子量:425.698
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](CO)NC(=O)CCCCCCC
    SMILES:CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](CO)NC(=O)CCCCCCC
  • C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.
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    TargetMolSC
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    ¥ 2,825.00
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