Name: AAF-CMK (trifluoroacetate salt)
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321091
Cas No:184901-82-4
常用名:AAF-CMK (trifluoroacetate salt)
IUPAC:(2S)-2-[(2S)-2-aminopropanamido]-N-[(2R)-4-chloro-3-oxo-1-phenylbutan-2-yl]propanamide; trifluoroacetic acid
IUPAC:(2S)-2-[(2S)-2-aminopropanamido]-N-[(2R)-4-chloro-3-oxo-1-phenylbutan-2-yl]propanamide; trifluoroacetic acid
InChI key:ZFZXFWAYCYJFIZ-VDWBQBBKSA-N

分子式:C18H23ClF3N3O5
分子量:453.84
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)CCl
SMILES:OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc1ccccc1)C(=O)CCl

Tripeptidyl peptidase II (TPPII) is a serine peptidase of the subtilisin-type which removes tripeptides from the free NH2 terminus of oligopeptides. AAF-CMK is an irreversible inhibitor of TPPII commonly used at 10-100 μM. It does not significantly interfere with the chymotrypsin-like activity of the proteasome. AAF-CMK also inhibits bleomycin hydrolase and puromycin-sensitive aminopeptidase when used at 50 μM.

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