Name: Cho-Arg (trifluoroacetate salt)
Rating: 5 (10 reviews)

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HIT ID:HIT214321096
Cas No:1609010-56-1
常用名:Cho-Arg (trifluoroacetate salt)
IUPAC:(1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl 6-[(2S)-2-amino-5-carbamimidamidopentanamido]hexanoate; bis(trifluoroacetic acid)
IUPAC:(1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-yl 6-[(2S)-2-amino-5-carbamimidamidopentanamido]hexanoate; bis(trifluoroacetic acid)
InChI key:JUXKTYZUYMWLSD-VFBLCMJGSA-N

分子式:C43H71F6N5O7
分子量:884.059
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCNC(=O)[C@@H](N)CCCNC(N)=N)[C@H](C)CCCC(C)C |t:21|
SMILES:OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCNC(=O)[C@@H](N)CCCNC(N)=N)[C@H](C)CCCC(C)C |t:21|

Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the caveolae-mediated endocytosis inhibitor genistein . It is cytotoxic to H1299 cells (IC50 = 88.5 μg/ml).

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