Name: para-amino-Blebbistatin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321122
Cas No:2097734-03-5
常用名:para-amino-Blebbistatin
IUPAC:(3aS)-1-(4-aminophenyl)-3a-hydroxy-6-methyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
IUPAC:(3aS)-1-(4-aminophenyl)-3a-hydroxy-6-methyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
InChI key:LYWLZINJPRNWFF-GOSISDBHSA-N

分子式:C18H17N3O2
分子量:307.353
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccc(N)cc1 |t:5|
SMILES:Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c1ccc(N)cc1 |t:5|

para-amino-Blebbistatin is a more water-soluble form of (S)-4'-nitro-blebbistatin , which is a more stable and less phototoxic form of (-)-blebbistatin .1,2,3 (-)-Blebbistatin is a selective cell-permeable inhibitor of non-muscle myosin II ATPases that rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC50s = 0.5-5 μM), while poorly inhibiting smooth muscle myosin (IC50 = 80 μM).2,3,4 Through these effects, it blocks apoptosis-related bleb formation, directed cell migration, and cytokinesis in vertebrate cells. However, prolonged exposure to blue light (450-490 nm) results in degradation of blebbistatin to an inactive product via cytotoxic intermediates, which may be problematic for its use in fluorescent live cell imaging applications.5,6 The addition of a 4'-amino group increases its water solubility, decreases the inherent fluorescence, stabilizes the molecule to circumvent its degradation by prolonged blue light exposure, and decreases its phototoxicity while retaining the in vitro and in vivo activity of blebbistatin.7 para-amino-Blebbistatin has the same stereochemistry as the active (-)-blebbistatin enantiomer.

市场产品/服务共显示1个结果

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymol随时为您提供帮助。

电话：400-820-0310

合作：info@screeningcompound.com

技术支持：tech@screeningcompound.com

客服：service@screeningcompound.com

正在加载 ~