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  3. HIT214321148
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HIT214321148
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HIT214321148
  • HIT ID:HIT214321148
  • Cas No:799268-65-8
  • 常用名:1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
    常用名:1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
  • IUPAC:[(2R)-2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphonic acid amine
    IUPAC:[(2R)-2-hydroxy-3-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyloxy]propoxy]phosphonic acid amine
  • InChI key:MQNJYFKSBIEJTA-PWZWHAFSSA-N
  • 分子式:C23H42NO7P
  • 分子量:475.563
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:N.CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC[C@@H](O)COP(O)(O)=O
    SMILES:N.CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OC[C@@H](O)COP(O)(O)=O
  • 1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is a precursor to 1-arachidonoyl glycerol . 1-Arachidonoyl lysophosphatidic acid binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.
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  • 供应商
    TargetMolSC
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    35日内发货
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    ¥ 2,200.00
    1

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