• CAS号
  • HIT ID
  • 供应商货号
  • SMILES
  • 化合物库

购物车
0
  2. 结构式搜索
  3. HIT214321156
有库存
HIT214321156
 sdf 文件
结构编辑
类似物检索
HIT214321156
  • HIT ID:HIT214321156
  • Cas No:1392830-09-9
  • 常用名:Caylin-2
  • IUPAC:4-[(4R,5S)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
    IUPAC:4-[(4R,5S)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-bis[4-(trifluoromethyl)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]piperazin-2-one
  • InChI key:HXLGOAAYXPLLCI-IZLXSDGUSA-N
  • 分子式:C32H30F6N4O4
  • 分子量:648.606
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C(F)(F)F)c(OC(C)C)c1 |t:6|
    SMILES:COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C(F)(F)F)c(OC(C)C)c1 |t:6|
  • Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-2 is a nutlin-3 analog in which trifluoromethyl groups have been substituted for chlorine on the 2 phenyl rings. At high concentrations, caylin-2 inhibits the growth of HCT116 cells with an IC50 of approximately 8 μM, making it about 10-fold less potent than nutlin-3. Interestingly, at concentrations between 5-100 nM, caylin-2 promotes the growth of HCT116 cells approximately 40% compared to untreated cells. The mechanism of the growth promoting properties of caylin-2 have not yet been elucidated.
市场产品/服务共显示1个结果
  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,930.00
    1

寻找合适的化合物库

您无法确定哪种化合物库最适合您的项目？或者您需要定制解决方案？Anymole随时为您提供帮助。
电话：400820-0310
合作：info@screeningcompound.com
技术支持：tech@screeningcompound.com
客服：service@screeningcompound.com
TargetMol | Target Loading
正在加载 ~
常用功能
使用指南化合物搜索在线客服返回顶层