Name: Tetrahydro-11-deoxy Cortisol
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214321160
Cas No:68-60-0
常用名:Tetrahydro-11-deoxy Cortisol
IUPAC:1-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-hydroxyethan-1-one
IUPAC:1-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aS)-1,7-dihydroxy-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-2-hydroxyethan-1-one
InChI key:UPTAPIKFKZGAGM-FAIYVORSSA-N

分子式:C21H34O4
分子量:350.499
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C
SMILES:[H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C

Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

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