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  3. HIT214321181
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HIT214321181
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HIT214321181
  • HIT ID:HIT214321181
  • Cas No:2132411-21-1
  • 常用名:QD-394
  • IUPAC:6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-5,8-dihydroquinazoline-5,8-dione
    IUPAC:6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-5,8-dihydroquinazoline-5,8-dione
  • InChI key:INZGOHBCPALCGM-UHFFFAOYSA-N
  • 分子式:C19H19N5O2
  • 分子量:349.394
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CN1CCN(CC1)c1ccc(NC2=CC(=O)c3ncncc3C2=O)cc1 |t:13|
    SMILES:CN1CCN(CC1)c1ccc(NC2=CC(=O)c3ncncc3C2=O)cc1 |t:13|
  • QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 μM. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 μM, respectively). QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
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  • 供应商
    TargetMolSC
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    货期
    35日内发货
    纯度
    -
    ¥ 1,230.00
    1

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