Name: SCH 38519
Rating: 5 (10 reviews)

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结构编辑

类似物检索

HIT ID:HIT214321189
Cas No:114970-20-6
常用名:SCH 38519
IUPAC:(1R,6R,10R,12R,19R,20S,21R)-21-(dimethylamino)-16,20-dihydroxy-12,19-dimethyl-7,11,23-trioxahexacyclo[17.3.1.0^{2,18}.0^{3,15}.0^{5,13}.0^{6,10}]tricosa-2,5(13),15,17-tetraene-4,8,14-trione
IUPAC:(1R,6R,10R,12R,19R,20S,21R)-21-(dimethylamino)-16,20-dihydroxy-12,19-dimethyl-7,11,23-trioxahexacyclo[17.3.1.0^{2,18}.0^{3,15}.0^{5,13}.0^{6,10}]tricosa-2,5(13),15,17-tetraene-4,8,14-trione
InChI key:JZGRDBGLULKCDD-HFJLKIIDSA-N

分子式:C24H25NO8
分子量:455.463
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@H]([C@H](O)[C@](C)(O1)c1cc(O)c3C(=O)C4=C(C(=O)c3c21)[C@@]1([H])OC(=O)C[C@@]1([H])O[C@@H]4C)N(C)C |c:17,TLB:20:21:8:2.3.4,5:4:21.9:8,10:9:8:2.3.4,THB:33:3:21.9:8|
SMILES:[H][C@]12C[C@H]([C@H](O)[C@](C)(O1)c1cc(O)c3C(=O)C4=C(C(=O)c3c21)[C@@]1([H])OC(=O)C[C@@]1([H])O[C@@H]4C)N(C)C |c:17,TLB:20:21:8:2.3.4,5:4:21.9:8,10:9:8:2.3.4,THB:33:3:21.9:8|

SCH 38519 is an isochromanequinone fungal metabolite originally isolated from Thermomonospora. It inhibits aggregation induced by thrombin , as well as inhibits serotonin secretion in human platelets (IC50s = 68 and 61 μg/ml, respectively). It inhibits the growth of various Gram-negative and Gram-positive bacteria (mean MICs = 122.1 and 0.92 μg/ml, respectively).

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