Name: Nornidulin
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321198
Cas No:33403-37-1
常用名:Nornidulin
IUPAC:4-(but-2-en-2-yl)-5,13,15-trichloro-6,14-dihydroxy-7,12-dimethyl-2,9-dioxatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one
IUPAC:4-(but-2-en-2-yl)-5,13,15-trichloro-6,14-dihydroxy-7,12-dimethyl-2,9-dioxatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one
InChI key:XEQDVQKKHOQZEP-UHFFFAOYSA-N

分子式:C19H15Cl3O5
分子量:429.67
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC=C(C)c1c(Cl)c(O)c(C)c2OC(=O)c3c(C)c(Cl)c(O)c(Cl)c3Oc12 |w:1.0|
SMILES:CC=C(C)c1c(Cl)c(O)c(C)c2OC(=O)c3c(C)c(Cl)c(O)c(Cl)c3Oc12 |w:1.0|

Nornidulin is a depsidone originally isolated from A. nidulans that has antibacterial activity against M. tuberculosis and M. ranoe as well as antifungal activity against T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 2 μg/ml) and has larvicidal activity toward Artemia (LC50 = 1.7 μg/ml). Nornidulin has cytotoxic activity in MOLT-3 cells (IC50 = 35.7 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >116.4 μM).

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