Name: Quazinone
Rating: 5 (10 reviews)

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HIT ID:HIT214321203
Cas No:70018-51-8
常用名:Quazinone
IUPAC:(3R)-6-chloro-3-methyl-2H,3H,5H,10H-imidazo[2,1-b]quinazolin-2-one
IUPAC:(3R)-6-chloro-3-methyl-2H,3H,5H,10H-imidazo[2,1-b]quinazolin-2-one
InChI key:BHZFZYLBVSWUMT-ZCFIWIBFSA-N

分子式:C11H10ClN3O
分子量:235.67
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:C[C@H]1N2Cc3c(Cl)cccc3NC2=NC1=O |c:14|
SMILES:C[C@H]1N2Cc3c(Cl)cccc3NC2=NC1=O |c:14|

Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smooth muscle cells in a concentration-dependent manner.3

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