Name: (±)5-iPF2α-VI
Rating: 5 (10 reviews)

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HIT ID:HIT214321228
Cas No:179094-11-2
常用名:(±)5-iPF2α-VI
别名:(±)5-iPF2α-VI
IUPAC:(6E)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(2Z)-oct-2-en-1-yl]cyclopentyl]-5-hydroxyhept-6-enoic acid
IUPAC:(6E)-7-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(2Z)-oct-2-en-1-yl]cyclopentyl]-5-hydroxyhept-6-enoic acid
InChI key:RZCPXIZGLPAGEV-SUHLLOIRSA-N

分子式:C20H34O5
分子量:354.487
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC\C=C/C[C@H]1[C@H](O)C[C@H](O)[C@H]1\C=C\C(O)CCCC(O)=O
SMILES:CCCCC\C=C/C[C@H]1[C@H](O)C[C@H](O)[C@H]1\C=C\C(O)CCCC(O)=O

Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress. (±)5-iPF2α-VI is an isoprostane from the unique Type VI class of isoprostanes. This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples.

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