Name: Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
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HIT ID:HIT214321241
Cas No:1234494-75-7
常用名:Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
常用名:Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
IUPAC:N''-[3-({3-[(3-{[bis(methylamino)methylidene]amino}propyl)amino]propyl}amino)propyl]-N,N'-dimethylguanidine tetrahydrochloride
IUPAC:N''-[3-({3-[(3-{[bis(methylamino)methylidene]amino}propyl)amino]propyl}amino)propyl]-N,N'-dimethylguanidine tetrahydrochloride
InChI key:ZCHKXZIIULPIMO-UHFFFAOYSA-N

分子式:C15H40Cl4N8
分子量:474.34
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.Cl.Cl.[#6]-[#7]\[#6](-[#7]-[#6])=[#7]\[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7]-[#6])-[#7]-[#6]
SMILES:Cl.Cl.Cl.Cl.[#6]-[#7]\[#6](-[#7]-[#6])=[#7]\[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]-[#7]-[#6]-[#6]-[#6]\[#7]=[#6](/[#7]-[#6])-[#7]-[#6]

Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used at a concentration of 10 μM.1It increases the level of H3K4 methylation, including H3K4me1 and H3K4me2 but not H3K9me2 levels, in HCT116 human colon carcinoma cells.2LSD inhibitor (1C) also induces re-expression of the Wnt signaling pathway proteins secreted frizzle-related protein 1 (SFRP1), SFRP4, and SFRP5, as well as the transcription factor GATA5, which are aberrantly silenced in HCT116 cells.

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