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  3. HIT214321248
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HIT214321248
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HIT214321248
  • HIT ID:HIT214321248
  • Cas No:2351843-48-4
  • 常用名:RAS inhibitor Abd-7
  • IUPAC:6-(2,3-dihydro-1,4-benzodioxin-5-yl)-N-{4-[(dimethylamino)methyl]phenyl}-2-methoxypyridin-3-amine
    IUPAC:6-(2,3-dihydro-1,4-benzodioxin-5-yl)-N-{4-[(dimethylamino)methyl]phenyl}-2-methoxypyridin-3-amine
  • InChI key:MJHHFDJNRRCUOB-UHFFFAOYSA-N
  • 分子式:C23H25N3O3
  • 分子量:391.471
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12
    SMILES:COc1nc(ccc1Nc1ccc(CN(C)C)cc1)-c1cccc2OCCOc12
  • RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders RAS-effector interactions and suppresses endogenous RAS-dependent signaling. Additionally, RAS inhibitor Abd-7 disrupts the PPI of different mutant KRAS proteins with PI3K, CRAF, RALGDS, as well as NRAS Q61H and HRAS G12V[1].
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  • 供应商
    TargetMolSC
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    货期
    5日内发货
    纯度
    -
    ¥ 5,980.00
    1

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