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  3. HIT214321252
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HIT214321252
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HIT214321252
  • HIT ID:HIT214321252
  • Cas No:2364458-49-9
  • 常用名:CAY10763
  • 别名:CAY10763
  • IUPAC:(2R)-N-(3,5-dimethoxyphenyl)-2-{[4-(hydroxyimino)-1-oxo-1,4-dihydronaphthalen-2-yl]amino}-3-phenylpropanamide
    IUPAC:(2R)-N-(3,5-dimethoxyphenyl)-2-{[4-(hydroxyimino)-1-oxo-1,4-dihydronaphthalen-2-yl]amino}-3-phenylpropanamide
  • InChI key:BTNMSAUAXSTYIU-RUZDIDTESA-N
  • 分子式:C27H25N3O5
  • 分子量:471.513
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:COc1cc(NC(=O)[C@@H](Cc2ccccc2)NC2=CC(=NO)c3ccccc3C2=O)cc(OC)c1 |w:20.21,t:18|
    SMILES:COc1cc(NC(=O)[C@@H](Cc2ccccc2)NC2=CC(=NO)c3ccccc3C2=O)cc(OC)c1 |w:20.21,t:18|
  • CAY10763 is a dual inhibitor of indolamine 2,3-dioxygenase 1 (IDO1; IC50= 46 nM) and STAT3 activation.1It binds to STAT3 (Kd= 530 nM) and selectively reduces the levels of STAT3 phosphorylated at the tyrosine in position 705 (STAT3Y705) over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells when used at a concentration of 500 nM. It also inhibits STAT3 nuclear translocation in SKOV3 cells. CAY10763 is cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively). It reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models when administered at doses of 100 and 10 mg/kg, respectively.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 3,850.00
    1

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