Name: Boromycin
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321254
Cas No:34524-20-4
常用名:Boromycin
IUPAC:hydrogen 5-{1-[(2-amino-3-methylbutanoyl)oxy]ethyl}-11,31-dihydroxy-12,12,16,25,32,32,36-heptamethyl-3,22-dioxo-4,18lambda3,20lambda3,23,26,37lambda3,38,40lambda3,41-nonaoxa-19lambda7-boraheptacyclo[17.17.1.1^{1,33}.1^{2,19}.1^{13,17}.1^{24,27}.0^{17,21}]hentetracont-7-ene-19,19,19-tris(ylium)-18,20,37,40-tetraide
IUPAC:hydrogen 5-{1-[(2-amino-3-methylbutanoyl)oxy]ethyl}-11,31-dihydroxy-12,12,16,25,32,32,36-heptamethyl-3,22-dioxo-4,18lambda3,20lambda3,23,26,37lambda3,38,40lambda3,41-nonaoxa-19lambda7-boraheptacyclo[17.17.1.1^{1,33}.1^{2,19}.1^{13,17}.1^{24,27}.0^{17,21}]hentetracont-7-ene-19,19,19-tris(ylium)-18,20,37,40-tetraide
InChI key:OOBFYEMEQCZLJL-UHFFFAOYSA-O

分子式:C45H74BNO15
分子量:879.89
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H+].CC(C)C(N)C(=O)OC(C)C1CC=CCCC(O)C(C)(C)C2CCC(C)C3(O2)[O-][B+3]24[O-]C3C(=O)OC3CC(CCCC(O)C(C)(C)C5CCC(C)C(O5)([O-]2)C([O-]4)C(=O)O1)OC3C |w:14.13|
SMILES:[H+].CC(C)C(N)C(=O)OC(C)C1CC=CCCC(O)C(C)(C)C2CCC(C)C3(O2)[O-][B+3]24[O-]C3C(=O)OC3CC(CCCC(O)C(C)(C)C5CCC(C)C(O5)([O-]2)C([O-]4)C(=O)O1)OC3C |w:14.13|

Boromycin is a boron-containing macrolide antibiotic that has been found in Streptomyces. Boromycin inhibits growth of B. subtilis (MIC = 0.05 μg/ml) and induces efflux of potassium ions from B. subtilis without affecting Na+/K+-ATPase activity. It decreases the synthesis of protein, RNA, and DNA in B. subtilis when used at a concentration of 0.05 μg/ml. It inhibits the growth of B. halodurans (MIC = 10 ng/ml) and inhibits the futalosine pathway of menaquinone synthesis in B. halodurans. Boromycin (3.4 nM) reverses bleomycin-induced cell cycle arrest at the G2 phase in Jurkat cells. It inhibits replication of the HIV-1 strains LAV-1 and RF and the HIV-2 strain LAV-2 in MT-4 cells (IC50s = 0.008, 0.11, and 0.007 μM, respectively). It also inhibits replication of a clinical isolate of HIV-1, strain KK-1, in MT-4 cells and peripheral blood mononuclear cells (PBMCs; IC50s = 0.14 and <0.1 μM, respectively).

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