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- HIT ID:HIT214321258
- Cas No:83807-40-3
- 常用名:Geranylgeranoic Acid
- InChI key:SZNLKILVMCHHSD-UHFFFAOYSA-N
- 分子式:C20H32O2
- 分子量:304.474
- 氢键供体数 (HBD):
- 氢键受体数 (HBA):
- LogP:
- Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).2It also inhibits lysine-specific demethylase 1 (LSD1; IC50= 46.97 μM).3
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