CAY10561 | CAS 933786-58-4 | AnyMole

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HIT214321260

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HIT214321260

HIT ID:HIT214321260
Cas No:933786-58-4
常用名:CAY10561
IUPAC:N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide
IUPAC:N-[1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl]-4-[4-(3-chlorophenyl)-1H-pyrazol-3-yl]-1H-pyrrole-2-carboxamide
InChI key:YMUYGRBBEDYUOP-UHFFFAOYSA-N

分子式:C22H17Cl2FN4O2
分子量:459.3
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)c(Cl)c1
SMILES:OCC(NC(=O)c1cc(c[nH]1)-c1n[nH]cc1-c1cccc(Cl)c1)c1ccc(F)c(Cl)c1

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 μM) and JNK3 (Ki = 4 μM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 μM.

市场产品/服务共显示2个结果

供应商
TargetMolSC
规格
货期
35日内发货
纯度
-
¥ 1,180.00
1
供应商
EnamineSC
规格
货期
4-6周
纯度
-
¥ 1,373.00
1

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