Name: Ipivivint
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321267
Cas No:1481617-15-5
常用名:Ipivivint
IUPAC:[(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl}pyridin-3-yl)methyl]dimethylamine
IUPAC:[(5-{3-[7-(3-fluorophenyl)-1H-imidazo[4,5-c]pyridin-2-yl]-1H-pyrazolo[3,4-b]pyridin-5-yl}pyridin-3-yl)methyl]dimethylamine
InChI key:YBBUGSYNPXTSGW-UHFFFAOYSA-N

分子式:C26H21FN8
分子量:464.508
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1
SMILES:CN(C)Cc1cncc(c1)-c1cnc2[nH]nc(-c3nc4cncc(-c5cccc(F)c5)c4[nH]3)c2c1

Ipivivint, a first-in-class, orally active and potent CDC-like kinase (CLK) inhibitor, inhibits CLK1 (IC50=1.4 μM), CLK2 (IC50=0.002 μM) and CLK3 (IC50=0.022 μM). Ipivivint reduces Wnt pathway signaling gene expression through inhibiting CLK activity and serine and arginine rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity. Ipivivint can be used for the research of cancer[1].

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