Name: FD-211
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321273
Cas No:162341-24-4
常用名:FD-211
IUPAC:(2R,3R,7S,7aR)-3-hydroxy-2,7-bis[(1E)-prop-1-en-1-yl]-2H,3H,5H,7H,7aH-furo[3,4-b]pyran-5-one
IUPAC:(2R,3R,7S,7aR)-3-hydroxy-2,7-bis[(1E)-prop-1-en-1-yl]-2H,3H,5H,7H,7aH-furo[3,4-b]pyran-5-one
InChI key:QXZDESIVIREXNJ-XQJSVKFYSA-N

分子式:C13H16O4
分子量:236.267
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12O[C@H](\C=C\C)[C@H](O)C=C1C(=O)O[C@H]2\C=C\C |c:9|
SMILES:[H][C@@]12O[C@H](\C=C\C)[C@H](O)C=C1C(=O)O[C@H]2\C=C\C |c:9|

FD-211 is a δ lactone originally isolated from M. lutea with anticancer activity.1 It is cytotoxic to adriamycin-susceptible P388, T-24, HeLa, A549, and HL-60 cancer cells (IC50s = 4, 0.5, 1, 1, and 0.2 μg/ml, respectively), as well as adriamycin-resistant HL-60/ADR cells (IC50 = 0.1 μg/ml). FD-211 also inhibits DNA, RNA, and protein synthesis in HeLa cells (IC50 = 1.25 μg/ml for all).

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