Name: CCT241533 dihydrochloride
Rating: 5 (10 reviews)

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HIT ID:HIT214321278
Cas No:1962925-28-5
常用名:CCT241533 dihydrochloride
别名:CCT 241533 dihydrochloride
IUPAC:4-fluoro-2-(4-{[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino}-6,7-dimethoxyquinazolin-2-yl)phenol dihydrochloride
IUPAC:4-fluoro-2-(4-{[(3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3-yl]amino}-6,7-dimethoxyquinazolin-2-yl)phenol dihydrochloride
InChI key:VCFVLTMSBOZYOU-FXKISCCRSA-N

分子式:C23H29Cl2FN4O4
分子量:515.41
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O
SMILES:Cl.Cl.COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O

Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes.

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