Name: Bottromycin A2
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321279
Cas No:15005-62-6
常用名:Bottromycin A2
IUPAC:methyl (3R)-3-[(2S,3S)-2-[(2S)-2-{[(14R,14aS)-6-tert-butyl-14-methyl-1,4,10-trioxo-3-(propan-2-yl)-1H,2H,3H,4H,5H,6H,9H,10H,12H,13H,14H,14aH-pyrrolo[1,2-a]1,4,7,10-tetraazacyclododecan-7-yl]amino}-3,3-dimethylbutanamido]-3-phenylbutanamido]-3-(1,3-thiazol-2-yl)propanoate
IUPAC:methyl (3R)-3-[(2S,3S)-2-[(2S)-2-{[(14R,14aS)-6-tert-butyl-14-methyl-1,4,10-trioxo-3-(propan-2-yl)-1H,2H,3H,4H,5H,6H,9H,10H,12H,13H,14H,14aH-pyrrolo[1,2-a]1,4,7,10-tetraazacyclododecan-7-yl]amino}-3,3-dimethylbutanamido]-3-phenylbutanamido]-3-(1,3-thiazol-2-yl)propanoate
InChI key:KSIZLOPUXFSFNR-YGDXDLJVSA-N

分子式:C42H62N8O7S
分子量:823.07
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]12[C@H](C)CCN1C(=O)CN=C(N[C@H](C(=O)N[C@@H]([C@@H](C)c1ccccc1)C(=O)N[C@H](CC(=O)OC)c1nccs1)C(C)(C)C)C(NC(=O)C(NC2=O)C(C)C)C(C)(C)C |w:10.10,@:52,@@:55|
SMILES:[H][C@@]12[C@H](C)CCN1C(=O)CN=C(N[C@H](C(=O)N[C@@H]([C@@H](C)c1ccccc1)C(=O)N[C@H](CC(=O)OC)c1nccs1)C(C)(C)C)C(NC(=O)C(NC2=O)C(C)C)C(C)(C)C |w:10.10,@:52,@@:55|

Bottromycin A2is an antibiotic originally isolated fromStreptomyces.1It blocks the binding of aminoacyl-tRNA to the A site of the 50S ribosome, inhibiting protein synthesis.2Bottromycin A2is active against clinical isolates of methicillin-resistantStaphylococcus aureus(MRSA) and vancomycin-resistantEnterococciwith MIC values of 1 and 0.5 μg/ml, respectively.

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