Name: Ciprostene (calcium salt)
Rating: 5 (10 reviews)

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HIT ID:HIT214321293
Cas No:81703-55-1
常用名:Ciprostene (calcium salt)
IUPAC:bis(5-[(2Z,3aS,5R,6R,6aR)-5-hydroxy-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3a-methyl-octahydropentalen-2-ylidene]pentanoic acid) calcium dihydride
IUPAC:bis(5-[(2Z,3aS,5R,6R,6aR)-5-hydroxy-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-3a-methyl-octahydropentalen-2-ylidene]pentanoic acid) calcium dihydride
InChI key:RRHMFTIPOKKJPM-FUHKURKISA-N

分子式:C44H72CaO8
分子量:769.13
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[CaH2].[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O.[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O
SMILES:[CaH2].[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O.[H][C@]12C\C(C[C@@]1(C)C[C@@H](O)[C@@H]2\C=C\[C@@H](O)CCCCC)=C\CCCC(O)=O

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.

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