Name: HLI373 dihydrochloride
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321294
Cas No:1782531-99-0
常用名:HLI373 dihydrochloride
IUPAC:5-{[3-(dimethylamino)propyl]amino}-3,10-dimethyl-2H,3H,4H,10H-pyrimido[4,5-b]quinoline-2,4-dione dihydrochloride
IUPAC:5-{[3-(dimethylamino)propyl]amino}-3,10-dimethyl-2H,3H,4H,10H-pyrimido[4,5-b]quinoline-2,4-dione dihydrochloride
InChI key:WUEMKAQTAIRDOA-UHFFFAOYSA-N

分子式:C18H25Cl2N5O2
分子量:414.33
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cl.CN(C)CCCNc1c2ccccc2n(C)c2nc(=O)n(C)c(=O)c12
SMILES:Cl.Cl.CN(C)CCCNc1c2ccccc2n(C)c2nc(=O)n(C)c(=O)c12

HLI373 dihydrochloride is a potent Hdm2 inhibitor, efficiently restraining the ubiquitin ligase activity of Hdm2 and effectively prompting apoptosis in DNA-damaging agent-sensitive tumor cells[1]. Additionally, HLI373 dihydrochloride exhibits antimalarial activity[2].

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