Name: 10-hydroxy Warfarin
Rating: 5 (10 reviews)

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HIT ID:HIT214321312
Cas No:83219-99-2
常用名:10-hydroxy Warfarin
IUPAC:4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one
IUPAC:4-hydroxy-3-(2-hydroxy-3-oxo-1-phenylbutyl)-2H-chromen-2-one
InChI key:BPZSPAZBZFZZBN-UHFFFAOYSA-N

分子式:C19H16O5
分子量:324.332
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC(=O)C(O)C(c1ccccc1)c1c(O)c2ccccc2oc1=O
SMILES:CC(=O)C(O)C(c1ccccc1)c1c(O)c2ccccc2oc1=O

10-hydroxy Warfarin is a metabolite of (R)-warfarin .1It is formed from (R)-warfarin by the cytochrome P450 (CYP) isoform CYP3A4. 10-hydroxy Warfarin is an inhibitor of CYP2C9 (IC50= 1.6 μM), the enzyme that converts (S)-warfarin to its 6-hydroxy warfarin and 7-hydroxy warfarin metabolites.2

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