Name: 13,14-dehydro-15-cyclohexyl Carbaprostacyclin
Rating: 5 (10 reviews)

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HIT ID:HIT214321315
Cas No:145375-81-1
常用名:13,14-dehydro-15-cyclohexyl Carbaprostacyclin
常用名:13,14-dehydro-15-cyclohexyl Carbaprostacyclin
IUPAC:5-[(2E,3aS,4S,5R,6aS)-5-hydroxy-4-[2-(1-hydroxycyclohexyl)ethynyl]-octahydropentalen-2-ylidene]pentanoic acid
IUPAC:5-[(2E,3aS,4S,5R,6aS)-5-hydroxy-4-[2-(1-hydroxycyclohexyl)ethynyl]-octahydropentalen-2-ylidene]pentanoic acid
InChI key:LGIPMFCHTFFLFR-PRYZLTTQSA-N

分子式:C21H30O4
分子量:346.467
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@@H](O)[C@H](C#CC3(O)CCCCC3)[C@@]1([H])C\C(C2)=C\CCCC(O)=O
SMILES:[H][C@]12C[C@@H](O)[C@H](C#CC3(O)CCCCC3)[C@@]1([H])C\C(C2)=C\CCCC(O)=O

13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is comparable to the potency of carbaprostacyclin.

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