Name: Filipin II
Rating: 5 (10 reviews)

有库存

sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321320
Cas No:38620-77-8
常用名:Filipin II
IUPAC:(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25Z,27S,28R)-3-hexyl-4,6,8,10,12,14,16,27-octahydroxy-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
IUPAC:(3R,4S,6S,8S,10R,12R,14R,16S,17E,19E,21E,23E,25Z,27S,28R)-3-hexyl-4,6,8,10,12,14,16,27-octahydroxy-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
InChI key:YMIXNQVKVPYZHL-UIMFPHPHSA-N

分子式:C35H58O10
分子量:638.839
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C/[C@H](O)[C@@H](C)OC1=O |c:36,t:28,30,32,34|
SMILES:CCCCCC[C@@H]1[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)\C(C)=C\C=C\C=C\C=C\C=C/[C@H](O)[C@@H](C)OC1=O |c:36,t:28,30,32,34|

Filipin II is a polyene and an active component of the polyene antibiotic filipin complex . [1] It has broad-spectrum antifungal activity, reducing growth of various fungi, including B. dermatitidis, C. neoformans, and H. capsulatum (MICs = 1-10 μg/ml). Filipin II inhibits ADP-stimulated respiration in rat liver mitochondria when used at a concentration of 3.5 mg/ml. [2] It also induces hemolysis of liposomes in a cholesterol-independent manner (IC50 = 0.5 μg/ml).[3]

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