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HIT214321326
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HIT214321326
  • HIT ID:HIT214321326
  • Cas No:220088-42-6
  • 常用名:Binucleine 2
  • IUPAC:N'-[1-(3-chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethylmethanimidamide
    IUPAC:N'-[1-(3-chloro-4-fluorophenyl)-4-cyano-1H-pyrazol-5-yl]-N,N-dimethylmethanimidamide
  • InChI key:MNCYLHJHZOUDLB-UHFFFAOYSA-N
  • 分子式:C13H11ClFN5
  • 分子量:291.71
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:CN(C)C=Nc1c(cnn1-c1ccc(F)c(Cl)c1)C#N |w:4.4|
    SMILES:CN(C)C=Nc1c(cnn1-c1ccc(F)c(Cl)c1)C#N |w:4.4|
  • Binucleine 2 is an isoform-specific and ATP-competitive inhibitor of Drosophila Aurora B kinase (Ki = 0.36 μM), a kinase involved in cell division. It is specific for Drosophila Aurora B kinase, inhibiting it in a dose-dependent manner, with minimal inhibition of human or X. laevis Aurora B kinases at concentrations up to 100 μM. Binucleine 2 induces mitotic and cytokinesis defects in Drosophila Kc167 cells. It prevents Drosophila S2 cells from assembling a contractile ring during cell division when used at a concentration of 40 μM but does not affect ring ingression, suggesting that Aurora B kinase activity is not required for that step.
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    TargetMolSC
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    35日内发货
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    ¥ 630.00
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