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  3. HIT214321339
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HIT214321339
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HIT214321339
  • HIT ID:HIT214321339
  • Cas No:478288-90-3
  • 常用名:(R)-Bromoenol lactone
  • IUPAC:(3R,6E)-6-(bromomethylidene)-3-(naphthalen-1-yl)oxan-2-one
    IUPAC:(3R,6E)-6-(bromomethylidene)-3-(naphthalen-1-yl)oxan-2-one
  • InChI key:BYUCSFWXCMTYOI-HBIYDYFMSA-N
  • 分子式:C16H13BrO2
  • 分子量:317.182
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Br\C=C1/CC[C@@H](C(=O)O1)c1cccc2ccccc12
    SMILES:Br\C=C1/CC[C@@H](C(=O)O1)c1cccc2ccccc12
  • The phospholipases are an extensive family of lipid hydrolases that function in cell signaling, digestion, membrane remodeling, and as venom components. The calcium-independent phospholipases (iPLA2) are a PLA2 subfamily closely associated with the release of arachidonic acid in response to physiologic stimuli. (R)-Bromoenol lactone ((R)-BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ). Unlike (S)-BEL, (R)-BEL does not inhibit iPLA2β except at high doses of 20-30 μM. (R)-BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 μM.
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  • 供应商
    TargetMolSC
    规格
    货期
    35日内发货
    纯度
    -
    ¥ 1,430.00
    1

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