Name: UA 62784
Rating: 5 (10 reviews)

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HIT ID:HIT214321347
Cas No:313367-92-9
常用名:UA 62784
IUPAC:4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
IUPAC:4-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-9H-fluoren-9-one
InChI key:SVICLWPFAQYZLX-UHFFFAOYSA-N

分子式:C23H15NO3
分子量:353.377
氢键供体数 (HBD):0
氢键受体数 (HBA):2
LogP:5.38
SMILES:COc1ccc(cc1)-c1cnc(o1)-c1cccc2C(=O)c3ccccc3-c12
SMILES:COc1ccc(cc1)-c1cnc(o1)-c1cccc2C(=O)c3ccccc3-c12

Inhibitor of microtubule polymerization in vitro. Interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Potentiates antiproliferative effects of vinblastine in H2B-GFP HeLa cells. Originally thought to inhibit CENP-E ATPase activity.

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