Name: CAY10773
Rating: 5 (10 reviews)

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HIT ID:HIT214321359
Cas No:1648546-79-5
常用名:CAY10773
IUPAC:1-(3,4-dichlorophenyl)-3-(3-{[(quinazolin-4-yl)amino]methyl}phenyl)urea
IUPAC:1-(3,4-dichlorophenyl)-3-(3-{[(quinazolin-4-yl)amino]methyl}phenyl)urea
InChI key:UFOVWAAXBJCADF-UHFFFAOYSA-N

分子式:C22H17Cl2N5O
分子量:438.31
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Clc1ccc(NC(=O)Nc2cccc(CNc3ncnc4ccccc34)c2)cc1Cl
SMILES:Clc1ccc(NC(=O)Nc2cccc(CNc3ncnc4ccccc34)c2)cc1Cl

CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HCV-29 cells (IC50= 23.19 μM). CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 μM but induces ferroptosis at concentrations greater than or equal to 6 μM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 (≥6 μM) also induces autophagy with incubation times longer than eight hours.

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