Name: Rasagiline-13C3 (mesylate)
Rating: 5 (10 reviews)

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HIT ID:HIT214321372
Cas No:1391052-18-8
常用名:Rasagiline-13C3 (mesylate)
别名:Rasagiline-13C3 (mesylate)
IUPAC:(1R)-N-[(1,2,3-13C3)prop-2-yn-1-yl]-2,3-dihydro-1H-inden-1-amine; methanesulfonic acid
IUPAC:(1R)-N-[(1,2,3-13C3)prop-2-yn-1-yl]-2,3-dihydro-1H-inden-1-amine; methanesulfonic acid
InChI key:JDBJJCWRXSVHOQ-UAWGACSXSA-N

分子式:C13H17NO3S
分子量:270.32
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CS(O)(=O)=O.[13CH]#[13C][13CH2]N[C@@H]1CCc2ccccc12
SMILES:CS(O)(=O)=O.[13CH]#[13C][13CH2]N[C@@H]1CCc2ccccc12

Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease.

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