Name: Bimatoprost grenod
Rating: 5 (10 reviews)

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HIT ID:HIT214321374
Cas No:1194396-71-8
常用名:Bimatoprost grenod
别名:15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
别名:15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α
IUPAC:(1E,3S)-1-[(1R,2R,3S,5R)-2-[(2Z)-6-(ethylcarbamoyl)hex-2-en-1-yl]-3,5-dihydroxycyclopentyl]-5-phenylpent-1-en-3-yl 6-(nitrooxy)hexanoate
IUPAC:(1E,3S)-1-[(1R,2R,3S,5R)-2-[(2Z)-6-(ethylcarbamoyl)hex-2-en-1-yl]-3,5-dihydroxycyclopentyl]-5-phenylpent-1-en-3-yl 6-(nitrooxy)hexanoate
InChI key:NTQMJNDRYSYWNJ-BPXWCPHMSA-N

分子式:C31H46N2O8
分子量:574.715
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@H](CCc1ccccc1)OC(=O)CCCCCON(=O)=O
SMILES:CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@H](CCc1ccccc1)OC(=O)CCCCCON(=O)=O

Bimatoprost grenod(15-(6-nitroxyhexanoyl)-17-phenyl trinor PGF2α) is a nitric oxide-donating derivative of 17-phenyl trinor PGF2α.1It increases cGMP levels in rabbit aqueous humor and iris ciliary body when topically administered at a concentration of 0.042%. Topical administration of 15-(6-nitroxylhexanoyl)-17-phenyl trinor PGF2α(0.14%) reduces intraocular hypertension (IOP) in a rabbit model of hypertonic saline-induced transient ocular pressure. It also reduces IOP in a cynomolgus monkey model of laser-induced ocular hypertension when administered topically at a concentration of 0.042%.

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