Name: Penicillide
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321384
Cas No:55303-92-9
常用名:Penicillide
IUPAC:16-hydroxy-6-[(1S)-1-hydroxy-3-methylbutyl]-7-methoxy-14-methyl-2,10-dioxatricyclo[10.4.0.0^{3,8}]hexadeca-1(12),3,5,7,13,15-hexaen-9-one
IUPAC:16-hydroxy-6-[(1S)-1-hydroxy-3-methylbutyl]-7-methoxy-14-methyl-2,10-dioxatricyclo[10.4.0.0^{3,8}]hexadeca-1(12),3,5,7,13,15-hexaen-9-one
InChI key:UOWGLBYIKHMCIS-HNNXBMFYSA-N

分子式:C21H24O6
分子量:372.417
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1c(ccc2Oc3c(O)cc(C)cc3COC(=O)c12)[C@@H](O)CC(C)C
SMILES:COc1c(ccc2Oc3c(O)cc(C)cc3COC(=O)c12)[C@@H](O)CC(C)C

Penicillide is a fungal metabolite originally isolated from Penicillium that has diverse biological activities. It is an inhibitor of calpain 2/m-calpain (IC50 = 7.1 μM) and acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 22.9 μM). It is also an antagonist of oxytocin receptors (IC50 = 67 μM). Penicillide inhibits RNA synthesis in P388 murine leukemia cells.

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