Name: PtdIns-(1,2-dioctanoyl) (sodium salt)
Rating: 5 (10 reviews)

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HIT ID:HIT214321387
Cas No:899827-36-2
常用名:PtdIns-(1,2-dioctanoyl) (sodium salt)
常用名:PtdIns-(1,2-dioctanoyl) (sodium salt)
IUPAC:[(2R)-2,3-bis(octanoyloxy)propoxy]({[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid sodium
IUPAC:[(2R)-2,3-bis(octanoyloxy)propoxy]({[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy})phosphinic acid sodium
InChI key:UTESADXKLSZCIO-RGISUMIPSA-N

分子式:C25H47NaO13P
分子量:609.602
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[Na].CCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)OC(=O)CCCCCCCjcExt:v:0:0
SMILES:[Na].CCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)OC(=O)CCCCCCCjcExt:v:0:0

The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(1,2-dioctanoyl) is a synthetic analog of natural phosphatidylinositol (PtdIns) containing C8:0 fatty acids at the sn-1 and sn-2 positions. The compound features the same inositol and diacyl glycerol (DAG) stereochemistry as that of the natural compound. The short fatty acid chains of this analog, compared to naturally-occurring PtdIns, gives it different physical properties including high solubility in aqueous media. PtdIns are phosphorylated to mono- (PtdIns-P; PIP), di- (PtdIns-P2; PIP2), and triphosphates (PtdIns-P3; PIP3). Hydrolysis of PtdIns-(4,5)-P2 by phosphoinositide (PI)-specific phospholipase C generates inositol triphosphate (IP3) and DAG which are key second messengers in an intricate biochemical signal transduction cascade.

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