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HIT214321401
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HIT214321401
  • HIT ID:HIT214321401
  • Cas No:890854-82-7
  • 常用名:CAY10503
  • IUPAC:4'-(4-hydroxyphenyl)-[1,1'-biphenyl]-3,5-diol
    IUPAC:4'-(4-hydroxyphenyl)-[1,1'-biphenyl]-3,5-diol
  • InChI key:DADMQAUVBPTTDT-UHFFFAOYSA-N
  • 分子式:C18H14O3
  • 分子量:278.307
  • 氢键供体数 (HBD):
  • 氢键受体数 (HBA):
  • LogP:
  • SMILES:Oc1ccc(cc1)-c1ccc(cc1)-c1cc(O)cc(O)c1
    SMILES:Oc1ccc(cc1)-c1ccc(cc1)-c1cc(O)cc(O)c1
  • CAY10503 is a proapoptotic, antiproliferative compound that is able to arrest cell cycle progression in the G0-G1 phase. CAY10503 inhibits the growth of HL60, multidrug resistant HL60R, and K562 cells with IC50 values of 7.0, 23, and 20 μM, respectively. Accumulation of HL60 cells in G0-G1 occurred within eight hours following treatment with 50 μM CAY10503, whereas 10 μM CAY10503 required 96 hours for cell cycle arrest to appear. CAY10503 also induces differentiation of HL60 cells into the following positive cells: CD14 (monocytic marker) as well as CD11b and CD11c (granulocytic markers). Approximately 60% of HL60 cells exposed to 10 μM CAY10503 expressed these markers within 72 hours.
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  • 供应商
    TargetMolSC
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    35日内发货
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    ¥ 696.00
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