Name: OH-Chol
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321434
Cas No:191173-82-7
常用名:OH-Chol
IUPAC:(1R,3aS,3bS,7S,9aR,9bS,11aR)-N-{2-[(2-hydroxyethyl)amino]ethyl}-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7-carboxamide
IUPAC:(1R,3aS,3bS,7S,9aR,9bS,11aR)-N-{2-[(2-hydroxyethyl)amino]ethyl}-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7-carboxamide
InChI key:IXLSSEJDKSHOEN-SDRVUZNUSA-N

分子式:C32H56N2O2
分子量:500.812
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NCCNCCO)[C@H](C)CCCC(C)C |t:9|
SMILES:[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)C(=O)NCCNCCO)[C@H](C)CCCC(C)C |t:9|

OH-Chol is a cationic cholesterol derivative.1 OH-Chol, as a component of lipoplexes with DOPE , has been used for siRNA delivery and gene silencing in MCF-7 cells, as well as in mice via intravenous injection, resulting in lipoplex accumulation in the liver. It has also been used in cationic nanoparticles in combination with Tween 80 to transfect pDNA and siRNA into PC3 mouse xenografts via intratumoral injection and with Tween 80 and folate-PEG2000-DSPE in a KB mouse xenograft model for intratumoral gene delivery.2

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