Name: hnRNPK-IN-1
Rating: 5 (10 reviews)

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HIT ID:HIT214321443
Cas No:2313528-04-8
常用名:hnRNPK-IN-1
IUPAC:(2E)-1-(4-methoxyphenyl)-3-[4-(morpholin-4-yl)-6-nitroquinolin-2-yl]prop-2-en-1-one
IUPAC:(2E)-1-(4-methoxyphenyl)-3-[4-(morpholin-4-yl)-6-nitroquinolin-2-yl]prop-2-en-1-one
InChI key:PFTIJUIEMIEMQH-RUDMXATFSA-N

分子式:C23H21N3O5
分子量:419.437
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1ccc(cc1)C(=O)\C=C\c1cc(N2CCOCC2)c2cc(ccc2n1)N(=O)=O
SMILES:COc1ccc(cc1)C(=O)\C=C\c1cc(N2CCOCC2)c2cc(ccc2n1)N(=O)=O

hnRNPK-IN-1 is a specific ligand that binds to the heterogeneous nuclear ribonucleoprotein K (hnRNPK) with high affinity, evidenced by Kd values of 4.6 μM and 2.6 μM determined using surface plasmon resonance (SPR) and microscale thermophoresis (MST), respectively. This binding event leads to the disruption of hnRNPK's interaction with the c-myc promoter, resulting in the inhibition of c-myc transcription. Additionally, hnRNPK-IN-1 induces apoptosis in Hela cells and exhibits potent anti-tumor activities[1].

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