Name: Z-(L-Arg)-AMC (hydrochloride)
Rating: 5 (10 reviews)

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HIT ID:HIT214321455
Cas No:70375-22-3
常用名:Z-(L-Arg)-AMC (hydrochloride)
IUPAC:benzyl N-[(1S)-4-carbamimidamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]butyl]carbamate hydrochloride
IUPAC:benzyl N-[(1S)-4-carbamimidamido-1-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]butyl]carbamate hydrochloride
InChI key:JYWCRDUTYUBXOL-FYZYNONXSA-N

分子式:C24H28ClN5O5
分子量:501.97
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.Cc1cc(=O)oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12
SMILES:Cl.Cc1cc(=O)oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)OCc3ccccc3)ccc12

Z-(L-Arg)-AMC is a fluorogenic substrate for trypsin, cathepsin B, and cathepsin H.1,2Upon enzymatic cleavage by trypsin, cathepsin B, or cathepsin H, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify trypsin, cathepsin B, and cathepsin H activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

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