Name: Laulimalide
Rating: 5 (10 reviews)

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类似物检索

HIT ID:HIT214321461
Cas No:115268-43-4
常用名:Laulimalide
IUPAC:(1R,3S,7S,8S,10S,12S,15E,18R)-7-hydroxy-12-[(1S,2E)-1-hydroxy-3-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]prop-2-en-1-yl]-3-methyl-5-methylidene-9,13,22-trioxatricyclo[16.3.1.0^{8,10}]docosa-15,19-dien-14-one
IUPAC:(1R,3S,7S,8S,10S,12S,15E,18R)-7-hydroxy-12-[(1S,2E)-1-hydroxy-3-[(2S)-4-methyl-3,6-dihydro-2H-pyran-2-yl]prop-2-en-1-yl]-3-methyl-5-methylidene-9,13,22-trioxatricyclo[16.3.1.0^{8,10}]docosa-15,19-dien-14-one
InChI key:MSBQEQDLFWWWMV-RPUUYYFUSA-N

分子式:C30H42O7
分子量:514.659
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:[H][C@]12C[C@]([H])(OC(=O)\C=C\C[C@@]3([H])O[C@@]([H])(CC=C3)C[C@@H](C)CC(=C)C[C@H](O)[C@]1([H])O2)[C@@H](O)\C=C\[C@@H]1CC(C)=CCO1 |c:17,41,t:8|
SMILES:[H][C@]12C[C@]([H])(OC(=O)\C=C\C[C@@]3([H])O[C@@]([H])(CC=C3)C[C@@H](C)CC(=C)C[C@H](O)[C@]1([H])O2)[C@@H](O)\C=C\[C@@H]1CC(C)=CCO1 |c:17,41,t:8|

Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.

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