Name: Luxeptinib
Rating: 5 (10 reviews)

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HIT ID:HIT214321470
Cas No:1616428-23-9
常用名:Luxeptinib
IUPAC:3-{3-fluoro-4-[7-(4-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]phenyl}-1-(2,4,6-trifluorophenyl)urea
IUPAC:3-{3-fluoro-4-[7-(4-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]phenyl}-1-(2,4,6-trifluorophenyl)urea
InChI key:MWHHJYUHCZWSLS-UHFFFAOYSA-N

分子式:C25H17F4N5O2
分子量:495.438
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cc1c[nH]c(n1)-c1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2c(F)cc(F)cc2F)cc1F
SMILES:Cc1c[nH]c(n1)-c1ccc(c2CNC(=O)c12)-c1ccc(NC(=O)Nc2c(F)cc(F)cc2F)cc1F

Luxeptinib (CG-806) is a novel pan-FLT3/pan-BTK inhibitor that is administered orally. It exhibits potent and reversible inhibition of these enzymes, acting through a non-covalent mechanism. Luxeptinib effectively induces cell cycle arrest, apoptosis, or autophagy in acute myeloid leukemia cells [1][2][3][4].

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