Name: Chk1-IN-5
Rating: 5 (10 reviews)

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sdf 文件

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HIT ID:HIT214321479
Cas No:2120398-39-0
常用名:Chk1-IN-5
别名:Chk1-IN-5
IUPAC:5-({5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile
IUPAC:5-({5-[2-(3-aminopropoxy)-4-fluoro-6-methoxyphenyl]-1H-pyrazol-3-yl}amino)pyrazine-2-carbonitrile
InChI key:CAAWSPMLCMFRMK-UHFFFAOYSA-N

分子式:C18H18FN7O2
分子量:383.387
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:COc1cc(F)cc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
SMILES:COc1cc(F)cc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1

Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1].

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