Name: GLS1 Inhibitor
Rating: 5 (10 reviews)

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HIT ID:HIT214321543
Cas No:1832646-52-2
常用名:GLS1 Inhibitor
IUPAC:(2S)-2-methoxy-2-phenyl-N-(5-{[(3R)-1-(pyridazin-3-yl)pyrrolidin-3-yl]amino}-1,3,4-thiadiazol-2-yl)acetamide
IUPAC:(2S)-2-methoxy-2-phenyl-N-(5-{[(3R)-1-(pyridazin-3-yl)pyrrolidin-3-yl]amino}-1,3,4-thiadiazol-2-yl)acetamide
InChI key:KLQLQDLJJUAEGT-ZBFHGGJFSA-N

分子式:C19H21N7O2S
分子量:411.48
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1
SMILES:CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cccnn2)s1)c1ccccc1

GLS1 inhibitor is an inhibitor of glutaminase 1 (GLS1; IC50= 0.021 μM).1It inhibits the growth of NCI H1703 non-small cell lung cancer (NSCLC) cellsin vitro(GI50= 0.011 μM). GLS1 inhibitor (100 mg/kg) reduces tumor growth, increases tumor levels of glutamine, and decreases tumor levels of glutamate and aspartate in an NCI H1703 mouse xenograft model.

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