Name: 14,15-dehydro Leukotriene B4
Rating: 5 (10 reviews)

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HIT ID:HIT214321571
Cas No:114616-11-4
常用名:14,15-dehydro Leukotriene B4
别名:14,15-dehydro Leukotriene B4
IUPAC:(5S,6Z,8E,10E,12R)-5,12-dihydroxyicosa-6,8,10-trien-14-ynoic acid
IUPAC:(5S,6Z,8E,10E,12R)-5,12-dihydroxyicosa-6,8,10-trien-14-ynoic acid
InChI key:PRCVOEPTHWOJMX-CHHAPGPYSA-N

分子式:C20H30O4
分子量:334.456
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCCC#CC[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
SMILES:CCCCCC#CC[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway. It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. At least two LTB4 receptors, termed BLT1 and BLT2, have been identified. 14,15-dehydro LTB4 is a LTB4 receptor antagonist that has a higher binding affinity for BLT1, demonstrating a Ki value of 27 nM, compared to BLT2, which has a Ki value of 473 nM. 14,15-dehydro LTB4 inhibits LTB4-induced release of lysozymes from rat polymorphonuclear leukoctyes with an IC50 value of 1 μM.

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