Name: 14,15-Leukotriene D4
Rating: 5 (10 reviews)

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HIT ID:HIT214321573
Cas No:75290-64-1
常用名:14,15-Leukotriene D4
别名:14,15-Leukotriene D4
IUPAC:(5Z,8Z,10E,12E,14R,15S)-14-{[(2R)-2-amino-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
IUPAC:(5Z,8Z,10E,12E,14R,15S)-14-{[(2R)-2-amino-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-15-hydroxyicosa-5,8,10,12-tetraenoic acid
InChI key:BUTLPEVGZIRJOA-SPCGXPCUSA-N

分子式:C25H40N2O6S
分子量:496.66
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CCCCC[C@H](O)[C@H](SC[C@H](N)C(=O)NCC(O)=O)\C=C\C=C\C=C/C\C=C/CCCC(O)=O
SMILES:CCCCC[C@H](O)[C@H](SC[C@H](N)C(=O)NCC(O)=O)\C=C\C=C\C=C/C\C=C/CCCC(O)=O

14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.

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