Name: Afizagabar
Rating: 5 (10 reviews)

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sdf 文件

结构编辑

类似物检索

HIT ID:HIT214321629
Cas No:1398496-82-6
常用名:Afizagabar
IUPAC:10-(4-fluoro-1-benzothiophen-2-yl)-13-methyl-6-oxa-4,11,12-triazatricyclo[7.5.0.0^{3,7}]tetradeca-1(9),2,7,10,12-pentaen-5-one
IUPAC:10-(4-fluoro-1-benzothiophen-2-yl)-13-methyl-6-oxa-4,11,12-triazatricyclo[7.5.0.0^{3,7}]tetradeca-1(9),2,7,10,12-pentaen-5-one
InChI key:WNUWGRVHGICCLS-UHFFFAOYSA-N

分子式:C19H12FN3O2S
分子量:365.38
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1 |t:1,3|
SMILES:CC1=NN=C(c2cc3c(F)cccc3s2)c2cc3oc(=O)[nH]c3cc2C1 |t:1,3|

Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal synaptic plasticity and exhibits pro-cognitive efficacy[1].

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