Name: NS 6740
Rating: 5 (10 reviews)

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HIT ID:HIT214321631
Cas No:753499-14-8
常用名:NS 6740
IUPAC:4-{5-[3-(trifluoromethyl)phenyl]furan-2-carbonyl}-1,4-diazabicyclo[3.2.2]nonane hydrochloride
IUPAC:4-{5-[3-(trifluoromethyl)phenyl]furan-2-carbonyl}-1,4-diazabicyclo[3.2.2]nonane hydrochloride
InChI key:QHSRBONTAYCFCC-UHFFFAOYSA-N

分子式:C19H20ClF3N2O2
分子量:400.83
氢键供体数 (HBD):
氢键受体数 (HBA):
LogP:
SMILES:Cl.FC(F)(F)c1cccc(c1)-c1ccc(o1)C(=O)N1CCN2CCC1CC2 |TLB:16:18:22.23:25.26|
SMILES:Cl.FC(F)(F)c1cccc(c1)-c1ccc(o1)C(=O)N1CCN2CCC1CC2 |TLB:16:18:22.23:25.26|

High affinity α7 nAChR partial agonist (Ki = 1.1 nM in rat; Emax < 10% of the response to ACh in rat and human). Inhibits ACh (IC50 = 2.7 nM) at α7 nAChR. Reduces LPS-induced TNF-α release from microglia enriched cultures. Anti-inflammatory.

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